Browsing by Author "Shen, Shan"

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    Distinct organization of two cortico-cortical feedback pathways
    (Springer Nature, 2022) Shen, Shan; Jiang, Xiaolong; Scala, Federico; Fu, Jiakun; Fahey, Paul; Kobak, Dmitry; Tan, Zhenghuan; Zhou, Na; Reimer, Jacob; Sinz, Fabian; Tolias, Andreas S.
    Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase–followed by a prolonged decrease–in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.