Browsing by Author "Sershen, Scott R."
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Item Optically-absorbing nanoparticles for enhanced tissue repair(2004-02-03) West, Jennifer L.; Drezek, Rebekah; Sershen, Scott R.; Halas, Nancy J.; Rice University; United States Patent and Trademark OfficeThis invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.Item Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery(2003-11-11) West, Jennifer L.; Sershen, Scott R.; Halas, Nancy J.; Oldenburg, Steven J.; Averitt, Richard D.; Rice University; United States Patent and Trademark OfficeA thermally sensitive polymer-particle composite that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical is disclosed. Metal nanoshells are nanoparticulate materials that are suitable for use in the present composites and can be made according to a process that includes optically tuning or tailoring their maximum optical absorption to any desired wavelength primarily by altering the ratio of the core diameter to the shell thickness. Preferred nanoshells are selected that strongly absorb light in the near-infrared and thus produce heat. These nanoshells are combined with a temperature-sensitive material to provide an implantable or injectable material for modulated drug delivery via external exposure to near-IR light. This invention provides a means to improve the quality of life for persons requiring multiple injections of a drug, such as diabetes mellitus patients.Item Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery(2002-08-06) West, Jennifer L.; Sershen, Scott R.; Halas, Nancy J.; Oldenburg, Steven J.; Averitt, Richard D.; Rice University; United States Patent and Trademark OfficeA thermally sensitive polymer-particle composite that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical is disclosed. Metal nanoshells are nanoparticulate materials that are suitable for use in the present composites and can be made according to a process that includes optically tuning or tailoring their maximum optical absorption to any desired wavelength primarily by altering the ratio of the core diameter to the shell thickness. Preferred nanoshells are selected that strongly absorb light in the near-infrared and thus produce heat. These nanoshells are combined with a temperature-sensitive material to provide an implantable or injectable material for modulated drug delivery via external exposure to near-IR light. This invention provides a means to improve the quality of life for persons requiring multiple injections of a drug, such as diabetes mellitus patients.