Browsing by Author "Pulukuri, Kiran Kumar"

Now showing 1 - 2 of 2
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    Synthesis of disorazoles and analogs thereof as potent anticancer agents
    (2022-10-11) Nicolaou, Kyrlacos C.; Bellavance, Gabriel; Buchman, Marek; Pulukuri, Kiran Kumar; Rigol, Stephan; Rice University; William Marsh Rice University; United States Patent and Trademark Office
    In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
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    Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith
    (2022-03-15) Nicolaou, Kyriacos C.; Erande, Rohan Diliprao; Vourloumis, Dionisios; Pulukuri, Kiran Kumar; Rigol, Stephan; Rice University; United States Patent and Trademark Office
    In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.