Browsing by Author "Prabhu, K. Sandeep"
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Item Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent(Wiley, 2014) Nicolaou, K.C.; Heretsch, Philipp; ElMarrouni, Abdelatif; Hale, Christopher R.H.; Pulukuri, Kiran K.; Kudva, Avinash K.; Narayan, Vivek; Prabhu, K. Sandeep; BioScience Research CollaborativeA catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule.