Browsing by Author "Patel, Abhijit A."

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    Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids
    (Cell Press, 2022) Cheng, Lauren Y.; Dai, Peng; Wu, Lucia R.; Patel, Abhijit A.; Zhang, David Yu; Bioengineering
    resulting fluorescence images and compared with tissue histopathology maps. The EGFﾖAlexa 647 signal correlated well with EGFR expression as indicated by immunohistochemistry. A classification algorithm for presence of neoplasia based on the signal from both contrast agents resulted in an area under the curve of 0.83. Regions
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    The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring
    (Elsevier, 2023) Batool, Syeda Maheen; Yekula, Anudeep; Khanna, Prerna; Hsia, Tiffaney; Gamblin, Austin S.; Ekanayake, Emil; Escobedo, Ana K.; You, Dong Gil; Castro, Cesar M.; Im, Hyungsoon; Kilic, Tugba; Garlin, Michelle Andrea; Skog, Johan; Dinulescu, Daniela M.; Dudley, Jonathan; Agrawal, Nishant; Cheng, Jordan; Abtin, Fereidoun; Aberle, Denise R.; Chia, David; Elashoff, David; Grognan, Tristan; Krysan, Kostyantyn; Oh, Scott S.; Strom, Charles; Tu, Michael; Wei, Fang; Xian, Rena R.; Skates, Steven J.; Zhang, David Y.; Trinh, Thi; Watson, Mark; Aft, Rebecca; Rawal, Siddarth; Agarwal, Ashutosh; Kesmodel, Susan B.; Yang, Changhuei; Shen, Cheng; Hochberg, Fred H.; Wong, David T. W.; Patel, Abhijit A.; Papadopoulos, Nickolas; Bettegowda, Chetan; Cote, Richard J.; Srivastava, Sudhir; Lee, Hakho; Carter, Bob S.; Balaj, Leonora
    The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays.