Browsing by Author "Offodile, Anaeze Chidiebele II"

Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    Development of Machine Learning Algorithms for the Prediction of Financial Toxicity in Localized Breast Cancer Following Surgical Treatment
    (American Society of Clinical Oncology, 2021) Sidey-Gibbons, Chris; Pfob, André; Asaad, Malke; Boukovalas, Stefanos; Lin, Yu-Li; Selber, Jesse Creed; Butler, Charles E.; Offodile, Anaeze Chidiebele II; James A. Baker III Institute for Public Policy
    PURPOSE: Financial burden caused by cancer treatment is associated with material loss, distress, and poorer outcomes. Financial resources exist to support patients but identification of need is difficult. We sought to develop and test a tool to accurately predict an individual's risk of financial toxicity based on clinical, demographic, and patient-reported data prior to initiation of breast cancer treatment. PATIENTS AND METHODS: We surveyed 611 patients undergoing breast cancer therapy at MD Anderson Cancer Center. We collected data using the validated COmprehensive Score for financial Toxicity (COST) patient-reported outcome measure alongside other financial indicators (credit score, income, and insurance status). We also collected clinical and perioperative data. We trained and tested an ensemble of machine learning (ML) algorithms (neural network, regularized linear model, support vector machines, and a classification tree) to predict financial toxicity. Data were randomly partitioned into training and test samples (2:1 ratio). Predictive performance was assessed using area-under-the-receiver-operating-characteristics-curve (AUROC), accuracy, sensitivity, and specificity. RESULTS: In our test sample (N = 203), 48 of 203 women (23.6%) reported significant financial burden. The algorithm ensemble performed well to predict financial burden with an AUROC of 0.85, accuracy of 0.82, sensitivity of 0.85, and specificity of 0.81. Key clinical predictors of financial burden from the linear model were neoadjuvant therapy (βregularized, .11) and autologous, rather than implant-based, reconstruction (βregularized, .06). Notably, radiation and clinical tumor stage had no effect on financial burden. CONCLUSION: ML models accurately predicted financial toxicity related to breast cancer treatment. These predictions may inform decision making and care planning to avoid financial distress during cancer treatment or enable targeted financial support. Further research is warranted to validate this tool and assess applicability for other types of cancer.
  • Thumbnail Image
    Item
    Do Private Equity Firms Target Struggling Hospitals for Acquisition?
    (James A. Baker III Institute for Public Policy, 2021) Offodile, Anaeze Chidiebele II; Ho, Vivian; James A. Baker III Institute for Public Policy
  • Thumbnail Image
    Item
    Is there a role for consumerism in the emerging value-based health care landscape?
    (2018) Offodile, Anaeze Chidiebele II; Ho, Vivian; James A. Baker III Institute for Public Policy
  • Thumbnail Image
    Item
    Making “Cents” for the Patient: Improving Health Care through Consumerism
    (James A. Baker III Institute for Public Policy, 2018) Offodile, Anaeze Chidiebele II; Ho, Vivian; James A. Baker III Institute for Public Policy
  • Thumbnail Image
    Item
    A Policy Primer on the Framing, Feasibility, and Trade-offs of “Medicare for All”
    (James A. Baker III Institute for Public Policy, 2019) Offodile, Anaeze Chidiebele II; Todd, Hannah; James A. Baker III Institute for Public Policy