Browsing by Author "Nardini, Marco"

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    Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
    (The American Society for Biochemistry and Molecular Biology, Inc., 2012) Salter, Mallory D.; Blouin, George C.; Soman, Jayashree; Singleton, Eileen Willey; Dewilde, Sylvia; Moens, Luc; Pesce, Alessandra; Nardini, Marco; Bolognesi, Martino; Olson, John S.
    Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry.