Browsing by Author "Meiyazhagan, Ashokkumar"
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Item Additive manufacture-assisted method for making structural elements having controlled failure characteristics(2023-08-15) Sajadi, Seyed Mohammad; Meiyazhagan, Ashokkumar; Boul, Peter; Rahman, Muhammad; Thaemlitz, Carl; Ajayan, Pulickel; Rice University; Saudi Arabian Oil Company; William Marsh Rice University; United States Patent and Trademark OfficeA process for making a layered multi-material structural element having controlled mechanical failure characteristics. The process includes the steps of: supplying a cementitious layer and forming a polymer layer on the cementitious layer by additive manufacture such that the polymer layer has a first thickness and the cementitious layer has a second thickness, wherein the polymer layer comprises a polymer and the cementitious layer comprises a cementitious material; and allowing the polymer from the polymer layer to suffuse into the cementitious layer for a period of time to obtain a suffused zone in the cementitious layer such that the suffused zone has a third thickness that is less than half the second thickness.Item Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy(MDPI, 2020) Sahin, Onur; Meiyazhagan, Ashokkumar; Ajayan, Pulickel M.; Krishnan, SunilNanoparticles activated by external beams, such as ionizing radiation, laser light, or magnetic fields, have attracted significant research interest as a possible modality for treating solid tumors. From producing hyperthermic conditions to generating reactive oxygen species, a wide range of externally activated mechanisms have been explored for producing cytotoxicity within tumors with high spatiotemporal control. To further improve tumoricidal effects, recent trends in the literature have focused on stimulating the immune system through externally activated treatment strategies that result in immunogenic cell death. By releasing inflammatory compounds known to initiate an immune response, treatment methods can take advantage of immune system pathways for a durable and robust systemic anti-tumor response. In this review, we discuss recent advancements in radiosensitizing and hyperthermic nanoparticles that have been tuned for promoting immunogenic cell death. Our review covers both preclinical and clinical results, as well as an overview of possible future work.Item Substitution of copper atoms into defect-rich molybdenum sulfides and their electrocatalytic activity(Royal Society of Chemistry, 2021) Wang, Zixing; Kannan, Harikishan; Su, Tonghui; Swaminathan, Jayashree; Shirodkar, Sharmila N.; Hernandez, Francisco C. Robles; Benavides, Hector Calderon; Vajtai, Robert; Yakobson, Boris I.; Meiyazhagan, Ashokkumar; Ajayan, Pulickel M.Studies on intercalation or substitution of atoms into layered two-dimensional (2D) materials are rapidly expanding and gaining significant consideration due to their importance in electronics, catalysts, batteries, sensors, etc. In this manuscript, we report a straightforward method to create sulphur (S) deficient molybdenum (Mo) sulfide (MoS2−x) structures and substitute them with zerovalent copper (Cu) atoms using a colloidal synthesis method. The synthesized materials were studied using several techniques to understand the proportion and position of copper atoms and the effect of copper functionalization. Specifically, the impact of change in the ratio of Cu : S and the hydrogen evolution reaction (HER) activity of the derived materials were evaluated. This technique paves the way for the synthesis of various functionalized 2D materials with a significant impact on their physical and chemical behavior making them potential candidates for catalysis and several other applications such as energy storage and the development of numerous functional devices.