Browsing by Author "Mandal, Debashis"

Now showing 1 - 4 of 4
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    Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    (2021-01-12) Nicolaou, Kyriacos C.; Lu, Min; Mandal, Debashis; Gangwar, Sanjeev; Chowdari, Naidu S.; Poudel, Yam B.; Rice University; BRISTOL-MYERS SQUIBB COMPANY; The Scripps Research Institute; United States Patent and Trademark Office
    In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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    Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    (2017-10-03) Nicolaou, Kyriacos C.; Lu, Min; Mandal, Debashis; Gangwar, Sanjeev; Chowdari, Naidu S; Poudel, Yam B.; Rice University; United States Patent and Trademark Office
    In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
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    Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    (2019-03-19) Nicolaou, Kyriacos C.; Lu, Min; Mandal, Debashis; Gangwar, Sanjeev; Chowdari, Naidu S.; Poudel, Yam B.; Rice University; The Scripps Research Institute; Bristol-Myers Squibb Company; United States Patent and Trademark Office
    In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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    Desacetoxytubulysin H and analogs thereof
    (2020-10-20) Nicolaou, Kyriacos C.; Vourloumis, Dionisios; Yin, Jun; Erande, Rohan; Mandal, Debashis; Klahn, Phillipp; Rice University; United States Patent and Trademark Office
    "In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. "