Browsing by Author "Lycke, Roy"
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Item Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes(Cell Press, 2023) Lycke, Roy; Kim, Robin; Zolotavin, Pavlo; Montes, Jon; Sun, Yingchu; Koszeghy, Aron; Altun, Esra; Noble, Brian; Yin, Rongkang; He, Fei; Totah, Nelson; Xie, Chong; Luan, Lan; Rice Neuroengineering InitiativeIntracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-nanoelectronic threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over 8 months at a markedly low charge injection of 0.25 nC/phase. Quantified histological analyses show that chronic ICMS by StimNETs induces no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially selective neuromodulation at low currents, which lessens risk of tissue damage or exacerbation of off-target side effects.Item Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording(Cell Press, 2020) He, Fei; Lycke, Roy; Ganji, Mehran; Xie, Chong; Luan, Lan; NeuroEngineering InitiativeImplanted electrodes provide one of the most important neurotechniques for fundamental and translational neurosciences by permitting time-resolved electrical detection of individual neurons in vivo. However, conventional rigid electrodes typically cannot provide stable, long-lasting recordings. Numerous interwoven biotic and abiotic factors at the tissue-electrode interface lead to short- and long-term instability of the recording performance. Making neural electrodes flexible provides a promising approach to mitigate these challenges on the implants and at the tissue-electrode interface. Here we review the recent progress of ultraflexible neural electrodes and discuss the engineering principles, the material properties, and the implantation strategies to achieve stable tissue-electrode interface and reliable unit recordings in living brains.