Browsing by Author "Luo, Yi"
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Item Equation governing the probability density evolution of multi-dimensional linear fractional differential systems subject to Gaussian white noise(Elsevier, 2023) Luo, Yi; Lyu, Meng-Ze; Chen, Jian-Bing; Spanos, Pol D.Stochastic fractional differential systems are important and useful in the mathematics, physics, and engineering fields. However, the determination of their probabilistic responses is difficult due to their non-Markovian property. The recently developed globally-evolving-based generalized density evolution equation (GE-GDEE), which is a unified partial differential equation (PDE) governing the transient probability density function (PDF) of a generic path-continuous process, including non-Markovian ones, provides a feasible tool to solve this problem. In the paper, the GE-GDEE for multi-dimensional linear fractional differential systems subject to Gaussian white noise is established. In particular, it is proved that in the GE-GDEE corresponding to the state-quantities of interest, the intrinsic drift coefficient is a time-varying linear function, and can be analytically determined. In this sense, an alternative low-dimensional equivalent linear integer-order differential system with exact closed-form coefficients for the original high-dimensional linear fractional differential system can be constructed such that their transient PDFs are identical. Specifically, for a multi-dimensional linear fractional differential system, if only one or two quantities are of interest, GE-GDEE is only in one or two dimensions, and the surrogate system would be a one- or two-dimensional linear integer-order system. Several examples are studied to assess the merit of the proposed method. Though presently the closed-form intrinsic drift coefficient is only available for linear stochastic fractional differential systems, the findings in the present paper provide a remarkable demonstration on the existence and eligibility of GE-GDEE for the case that the original high-dimensional system itself is non-Markovian, and provide insights for the physical-mechanism-informed determination of intrinsic drift and diffusion coefficients of GE-GDEE of more generic complex nonlinear systems.Item Global Increase of Antibiotic Resistance Genes in Conjugative Plasmids(American Society for Microbiology, 2023) Wang, Xiaolong; Zhang, Hanhui; Long, Xiang; Xu, Ximing; Ren, Hongqiang; Mao, Daqing; Alvarez, Pedro J. J.; Luo, YiAntibiotic resistance is propagating worldwide, but the predominant dissemination mechanisms are not fully understood. Here, we report that antibiotic resistance gene (ARG) abundance in conjugative plasmids that are recorded in the National Center for Biotechnology Information (NCBI) RefSeq plasmid database is increasing globally, which is likely a key factor in the propagation of resistance. ARG abundance in plasmids increased by 10-fold on a global scale from the year 2000 to the year 2020 (from 0.25 to 2.93 ARG copies/plasmid), with a more pronounced increase being observed in low-to-middle income countries. This increasing trend of plasmid-borne ARGs was corroborated by bootstrap resampling from each year of the NCBI RefSeq plasmid database. The results of a correlation analysis imply that if antibiotic consumption keeps growing at the current rates, a 2.7-fold global increase in the ARG abundance of clinically relevant plasmids may be reached by 2030. High sequence similarities of clinically relevant, conjugative plasmids that are isolated both from clinics and from the environment raise concerns about the environmental resistome serving as a potential ARG maintenance reservoir that facilitates transmission across these ecological boundaries. IMPORTANCE Antibiotic resistance propagation is a significant concern due to its projected impacts on both global health and the economy. However, global propagation mechanisms are not fully understood, including regional and temporal trends in the abundance of resistance plasmids that facilitate antibiotic resistance gene (ARG) dissemination. This unprecedented study reports that ARG abundance in the conjugative plasmids that are recorded in the National Center for Biotechnology Information (NCBI) database and harbor ARGs is increasing globally with antibiotic consumption, especially in low-to-medium income countries. Through network and comparative genomic analyses, we also found high sequence similarities of clinically relevant conjugative resistance plasmids that were isolated from clinical and environmental sources, suggesting transmission between these ecological boundaries. Therefore, this study informs the One Health perspective to develop effective strategies by which to curtail the propagation of plasmid-borne antibiotic resistance.Item Hysteria: Medicine as a Vehicle for Gendered Social Control(Rice University, 2019) Hooper, Ginger; Li, Laura; Luo, YiThis paper analyzes the historical phenomenon of hysteria, a psychiatric label once commonly applied to female patients to explain a variety of physical ailments and deviant behaviors. Beginning with an examination of its ancient historical roots, the paper then focuses on hysteria’s application in Victorian England. Hysteria can be viewed as both cause and consequence of a male-dominated society and medical profession, used a means of enforcing traditional gender roles and expectations for feminine sexuality. By emphasizing and pathologizing the female reproductive organs, diagnoses of hysteria reinforced cultural ideas about women’s reproductive role and the male physician’s right to regulate that role. In these ways, hysteria is a compelling example of the socially contingent nature of illness and the power of medicine as a tool of social control.Item Noradrenaline tracks emotional modulation of attention in human amygdala(Elsevier, 2023) Bang, Dan; Luo, Yi; Barbosa, Leonardo S.; Batten, Seth R.; Hadj-Amar, Beniamino; Twomey, Thomas; Melville, Natalie; White, Jason P.; Torres, Alexis; Celaya, Xavier; Ramaiah, Priya; McClure, Samuel M.; Brewer, Gene A.; Bina, Robert W.; Lohrenz, Terry; Casas, Brooks; Chiu, Pearl H.; Vannucci, Marina; Kishida, Kenneth T.; Witcher, Mark R.; Montague, P. ReadThe noradrenaline (NA) system is one of the brain’s major neuromodulatory systems; it originates in a small midbrain nucleus, the locus coeruleus (LC), and projects widely throughout the brain.1,2 The LC-NA system is believed to regulate arousal and attention3,4 and is a pharmacological target in multiple clinical conditions.5,6,7 Yet our understanding of its role in health and disease has been impeded by a lack of direct recordings in humans. Here, we address this problem by showing that electrochemical estimates of sub-second NA dynamics can be obtained using clinical depth electrodes implanted for epilepsy monitoring. We made these recordings in the amygdala, an evolutionarily ancient structure that supports emotional processing8,9 and receives dense LC-NA projections,10 while patients (n = 3) performed a visual affective oddball task. The task was designed to induce different cognitive states, with the oddball stimuli involving emotionally evocative images,11 which varied in terms of arousal (low versus high) and valence (negative versus positive). Consistent with theory, the NA estimates tracked the emotional modulation of attention, with a stronger oddball response in a high-arousal state. Parallel estimates of pupil dilation, a common behavioral proxy for LC-NA activity,12 supported a hypothesis that pupil-NA coupling changes with cognitive state,13,14 with the pupil and NA estimates being positively correlated for oddball stimuli in a high-arousal but not a low-arousal state. Our study provides proof of concept that neuromodulator monitoring is now possible using depth electrodes in standard clinical use.