Browsing by Author "Leach, David"

Now showing 1 - 2 of 2
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    Hydrogel delivery of sting immunotherapy for treatment cancer
    (2024-04-30) Young, Simon; Leach, David; Hartgerink, Jeffrey D.; Rice University; The Board of Regents of the University of Texas System; United States Patent and Trademark Office
    In one aspect, the present disclosure provides for novel compositions of matter comprising multi domain peptide (MDP) hydrogels and cyclic dinucleotides (CDNs). Also disclosed are method of using such compositions in the treatment of cancer, including in particular the treatment of head and neck cancers, such as those resistant to CDN therapy.
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    Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase
    (2025-03-18) Hartgerink, Jeffrey; Sikora, Andrew G.; Leach, David; Newton, Jared M.; Young, Simon; Rice University; Baylor College of Medicine; The Board of Regents of the University of Texas System; United States Patent and Trademark Office
    Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.