Browsing by Author "Kang, Byunguk"

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    Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
    (2020-12-08) Ho, Michelle; Suh, Junghae; Yamagami, Momona; Gough, Veronica; Kang, Byunguk; Rice University; United States Patent and Trademark Office
    The present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VP1 or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.