Browsing by Author "Genin, Guy M."
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Item Measurement of mechanical tractions exerted by cells within three-dimensional matrices(Nature Publishing Group, 2010) Legant, Wesley R.; Miller, Jordan S.; Blakely, Brandon L.; Cohen, Daniel M.; Genin, Guy M.; Chen, Christopher S.Quantitative measurements of cell-generated forces have heretofore required that cells be cultured on two-dimensional substrates. We describe a technique to quantitatively measure three-dimensional traction forces exerted by cells fully encapsulated within well-defined elastic hydrogel matrices. We apply this approach to measure tractions from a variety of cell types and contexts, and reveal patterns of force generation attributable to morphologically distinct regions of cells as they extend into the surrounding matrix.