Browsing by Author "Dube, Queen"

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    AutoSyP: A Low-Cost, Low-Power Syringe Pump for Use in Low-Resource Settings
    (The American Society of Tropical Medicine and Hygiene, 2016) Juarez, Alexa; Maynard, Kelley; Skerrett, Erica; Molyneux, Elizabeth; Richards-Kortum, Rebecca; Dube, Queen; Oden, Z. Maria; Rice 360: Institute for Global Health Technologies
    This article describes the design and evaluation of AutoSyP, a low-cost, low-power syringe pump intended to deliver intravenous (IV) infusions in low-resource hospitals. A constant-force spring within the device provides mechanical energy to depress the syringe plunger. As a result, the device can run on rechargeable battery power for 66 hours, a critical feature for low-resource settings where the power grid may be unreliable. The device is designed to be used with 5- to 60-mL syringes and can deliver fluids at flow rates ranging from 3 to 60 mL/hour. The cost of goods to build one AutoSyP device is approximately $500. AutoSyP was tested in a laboratory setting and in a pilot clinical study. Laboratory accuracy was within 4% of the programmed flow rate. The device was used to deliver fluid to 10 healthy adult volunteers and 30 infants requiring IV fluid therapy at Queen Elizabeth Central Hospital in Blantyre, Malawi. The device delivered fluid with an average mean flow rate error of −2.3% ± 1.9% for flow rates ranging from 3 to 60 mL/hour. AutoSyP has the potential to improve the accuracy and safety of IV fluid delivery in low-resource settings.
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    Evaluation of a Point-of-Care Test for Bilirubin in Malawi
    (American Academy of Pediatrics, 2022) Shapiro, Alyssa; Anderson, Jessica; Mtenthaonga, Prince; Kumwenda, Watson; Bond, Meaghan; Schwarz, Richard; Carns, Jennifer; Johnston, Ryan; Dube, Queen; Chiume, Msandeni; Richards-Kortum, Rebecca; Rice 360° Institute for Global Health
    OBJECTIVES: BiliSpec is a low-cost spectrophotometric reader and disposable paper-based strip to quantify total serum bilirubin from several blood drops. This study was a prospective evaluation of BiliSpec in 2 neonatal wards in Malawi compared with a reference standard bilirubinometer over a large range of bilirubin and hematocrit levels. METHODS: The accuracy of BiliSpec and a transcutaneous bilirubinometer were compared with the reference standard of spectrophotometry for 475 blood samples collected from 375 subjects across a range of total serum bilirubin concentrations from 0.0 to 33.7 mg/dL. The development of error grids to assess the clinical effects of measurement differences is reported. RESULTS: BiliSpec was found to have a mean bias of −0.48 mg/dL and 95% limits of agreement of −5.09 mg/dL to +4.12 mg/dL. Results show 90.7% of BiliSpec measurements would have resulted in the same clinical decision as the reference standard, whereas 55.0% of transcutaneous bilirubin measurements would have resulted in the same clinical decision as the reference standard. CONCLUSIONS: This evaluation supports use of BiliSpec to provide accurate, low-cost, point-of-care bilirubin measurements in low-resource hospitals. Future work is needed to evaluate BiliSpec among a larger number of users.
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    Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings
    (National Academy of Sciences, 2017) Keahey, Pelham A.; Simeral, Mathieu L.; Schroder, Kristofer J.; Bond, Meaghan M.; Mtenthaonnga, Prince J.; Miros, Robert H.; Dube, Queen; Richards-Kortum, Rebecca R.
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    Quantifying health facility service readiness for small and sick newborn care: comparing standards-based and WHO level-2 + scoring for 64 hospitals implementing with NEST360 in Kenya, Malawi, Nigeria, and Tanzania
    (Springer Nature, 2024) Penzias, Rebecca E.; Bohne, Christine; Gicheha, Edith; Molyneux, Elizabeth M.; Gathara, David; Ngwala, Samuel K.; Zimba, Evelyn; Rashid, Ekran; Odedere, Opeyemi; Dosunmu, Olabisi; Tillya, Robert; Shabani, Josephine; Cross, James H.; Ochieng, Christian; Webster, Harriet H.; Chiume, Msandeni; Dube, Queen; Wainaina, John; Kassim, Irabi; Irimu, Grace; Adudans, Steve; James, Femi; Tongo, Olukemi; Ezeaka, Veronica Chinyere; Salim, Nahya; Masanja, Honorati; Oden, Maria; Richards-Kortum, Rebecca; Hailegabriel, Tedbabe; Gupta, Gagan; Cousens, Simon; Lawn, Joy E.; Ohuma, Eric O.; Mchoma, Christina; Bilitinyu, Joseph; Chalamanda, Pius; Dzinkambani, Mirriam; Mhango, Ruth; Stevens, Fanny; Mulungu, Joseph; Makhumula, Blessings; Banda, Loveness; Banda, Charles; Chumbi, Brian; Banda, Chifundo; Chimombo, Evelyn; Nyasulu, Nicodemus; Ndau, Innocent; Kumwembe, Pilirani; Kerubo, Edna; Ambuso, Nyphry; Koech, Kevin; Waithaka, Noel; Wakhungu, Calet; Otieno, Steven; Bahati, Felix; Ayaga, Josphine; Obure, Jedida; Nderitu, Nellius; Mtambo, Violet; Mkude, George; Miraji, Mustapha; Shayo, Caroline; Nambombi, Camilius; Cyrilo, Christopher; Aderounmu, Temilade; Wale, Akingbehin Wakeel; Yemisi, Odeleye Victoria; Dupe, Akinola Amudalat; Awolowo, Samuel; A., Ojelabi Oluwaseun; Ovuoraye, John Ajiwohwodoma; Mujaid, Balogun Adeleke; Fetuga, Adedoyin; Okanlawon, Juilana; Awosika, Flora; Michael, Awotayo Olasupo; Abiodun, Omotayo Adegboyega; with the Health Facility Assessment Data Collection Learning Collaborative Group; Rice360 Institute for Global Health Technologies
    Service readiness tools are important for assessing hospital capacity to provide quality small and sick newborn care (SSNC). Lack of summary scoring approaches for SSNC service readiness means we are unable to track national targets such as the Every Newborn Action Plan targets.
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    Target product profiles for neonatal care devices: systematic development and outcomes with NEST360 and UNICEF
    (Springer Nature, 2023) Kirby, Rebecca P.; Molyneux, Elizabeth M.; Dube, Queen; McWhorter, Cindy; Bradley, Beverly D.; Gartley, Martha; Oden, Z. Maria; Richards-Kortum, Rebecca; Werdenberg-Hall, Jennifer; Kumara, Danica; Liaghati-Mobarhan, Sara; Heenan, Megan; Bond, Meaghan; Ezeaka, Chinyere; Salim, Nahya; Irimu, Grace; Palamountain, Kara M.; Manasyan, Albert; Worm, Anna; Zuechner, Antke; Chepkemoi, Audrey; Tembo, Bentry; Trubo, Casey; Mudenyanga, Chishamiso; Wald, Daniel; Goldfarb, David; Gicheha, Edith; Asma, Elizabeth; Ciccone, Emily; Mbale, Emmie; Gheorghe, Florin; Dumont, Guy; Naburi, Helga; Pernica, Jeffrey; Appiah, John; Strysko, Jonathan; Langton, Josephine; Lawn, Joy; Klein, Kate; Kawaza, Kondwani; Gandrup-Marino, Kristoffer; Lloyd, Lizel; Woo Kinshella, Maggie; Chise, Mamiki; Myszkowski, Marc; Mkony, Martha Franklin; Waiyego, Mary; Khoory, Matthew; Medvedev, Melissa; Chiume, Msandeni; Spotswood, Naomi; Mataruse, Noah; Lufesi, Norman; Lincetto, Ornella; Lavoie, Pascal; Mbuthia, Rachel; Chifisi, Rhoda; Owino, Rita; Moshiro, Robert; Mbwasi, Ronald; Akech, Sam; Shah, Sona; Reschwamm, Steffen; Adudans, Steve; Mogotsi, Thabiso; Karlen, Walter; Demeke, Zelalem; the TPP Survey, Consensus Meeting Participants Collaborative Authorship Group; Rice360 Institute for Global Health Technologies
    Medical devices are critical to providing high-quality, hospital-based newborn care, yet many of these devices are unavailable in low- and middle-income countries (LMIC) and are not designed to be suitable for these settings. Target Product Profiles (TPPs) are often utilised at an early stage in the medical device development process to enable user-defined performance characteristics for a given setting. TPPs can also be applied to assess the profile and match of existing devices for a given context.