Browsing by Author "Darwiche, Hawraa"
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Item Development of a multimodal foveated endomicroscope for the detection of oral cancer(The Optical Society, 2017) Shadfan, Adam; Darwiche, Hawraa; Blanco, Jesus; Gillenwater, Ann; Richards-Kortum, Rebecca; Tkaczyk, Tomasz S.A multimodal endomicroscope was developed for cancer detection that combines hyperspectral and confocal imaging through a single foveated objective and a vibrating optical fiber bundle. Standard clinical examination has a limited ability to identify early stage oral cancer. Optical detection methods are typically restricted by either achievable resolution or a small field-of-view. By combining high resolution and widefield spectral imaging into a single probe, a device was developed that provides spectral and spatial information over a 5 mm field to locate suspicious lesions that can then be inspected in high resolution mode. The device was evaluated on ex vivo biopsies of human oral tumors.