Browsing by Author "Chua, Eng Guan"

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    Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock
    (Springer Nature, 2023) Hassan, Shamshad Ul; Chua, Eng Guan; Paz, Erwin A.; Tay, Chin Yen; Greeff, Johan C.; Palmer, Dieter G.; Dudchenko, Olga; Aiden, Erez Lieberman; Martin, Graeme B.; Kaur, Parwinder; Center for Theoretical Biological Physics
    Gastrointestinal (GIT) helminthiasis is a global problem that affects livestock health, especially in small ruminants. One of the major helminth parasites of sheep and goats, Teladorsagia circumcincta, infects the abomasum and causes production losses, reductions in weight gain, diarrhoea and, in some cases, death in young animals. Control strategies have relied heavily on the use of anthelmintic medication but, unfortunately, T. circumcincta has developed resistance, as have many helminths. Vaccination offers a sustainable and practical solution, but there is no commercially available vaccine to prevent Teladorsagiosis. The discovery of new strategies for controlling T. circumcincta, such as novel vaccine targets and drug candidates, would be greatly accelerated by the availability of better quality, chromosome-length, genome assembly because it would allow the identification of key genetic determinants of the pathophysiology of infection and host-parasite interaction. The available draft genome assembly of T. circumcincta (GCA_002352805.1) is highly fragmented and thus impedes large-scale investigations of population and functional genomics.