Browsing by Author "Chowdari, Naidu S."

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    Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    (2021-01-12) Nicolaou, Kyriacos C.; Lu, Min; Mandal, Debashis; Gangwar, Sanjeev; Chowdari, Naidu S.; Poudel, Yam B.; Rice University; BRISTOL-MYERS SQUIBB COMPANY; The Scripps Research Institute; United States Patent and Trademark Office
    In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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    Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    (2019-03-19) Nicolaou, Kyriacos C.; Lu, Min; Mandal, Debashis; Gangwar, Sanjeev; Chowdari, Naidu S.; Poudel, Yam B.; Rice University; The Scripps Research Institute; Bristol-Myers Squibb Company; United States Patent and Trademark Office
    In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.