Browsing by Author "Chiume, Msandeni"
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Item Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study(Springer Nature, 2023) Murless-Collins, Sarah; Kawaza, Kondwani; Salim, Nahya; Molyneux, Elizabeth M.; Chiume, Msandeni; Aluvaala, Jalemba; Macharia, William M.; Ezeaka, Veronica Chinyere; Odedere, Opeyemi; Shamba, Donat; Tillya, Robert; Penzias, Rebecca E.; Ezenwa, Beatrice Nkolika; Ohuma, Eric O.; Cross, James H.; Lawn, Joy E.; Bokea, Helen; Bohne, Christine; Waiyego, Mary; Irimu, Grace; Ogueji, Ifeanyichukwu Anthony; Jenkins, Georgia; Tongo, Olukemi O.; Fajolu, Iretiola; Olutekunbi, Nike; Paul, Cate; Baraka, Jitihada; Kirby, Rebecca; Palamountain, Kara; the NEST360 Infection GroupThirty million small and sick newborns worldwide require inpatient care each year. Many receive antibiotics for clinically diagnosed infections without blood cultures, the current ‘gold standard’ for neonatal infection detection. Low neonatal blood culture use hampers appropriate antibiotic use, fuelling antimicrobial resistance (AMR) which threatens newborn survival. This study analysed the gap between blood culture use and antibiotic prescribing in hospitals implementing with Newborn Essential Solutions and Technologies (NEST360) in Kenya, Malawi, Nigeria, and Tanzania.Item Evaluation of a Point-of-Care Test for Bilirubin in Malawi(American Academy of Pediatrics, 2022) Shapiro, Alyssa; Anderson, Jessica; Mtenthaonga, Prince; Kumwenda, Watson; Bond, Meaghan; Schwarz, Richard; Carns, Jennifer; Johnston, Ryan; Dube, Queen; Chiume, Msandeni; Richards-Kortum, Rebecca; Rice 360° Institute for Global HealthOBJECTIVES: BiliSpec is a low-cost spectrophotometric reader and disposable paper-based strip to quantify total serum bilirubin from several blood drops. This study was a prospective evaluation of BiliSpec in 2 neonatal wards in Malawi compared with a reference standard bilirubinometer over a large range of bilirubin and hematocrit levels. METHODS: The accuracy of BiliSpec and a transcutaneous bilirubinometer were compared with the reference standard of spectrophotometry for 475 blood samples collected from 375 subjects across a range of total serum bilirubin concentrations from 0.0 to 33.7 mg/dL. The development of error grids to assess the clinical effects of measurement differences is reported. RESULTS: BiliSpec was found to have a mean bias of −0.48 mg/dL and 95% limits of agreement of −5.09 mg/dL to +4.12 mg/dL. Results show 90.7% of BiliSpec measurements would have resulted in the same clinical decision as the reference standard, whereas 55.0% of transcutaneous bilirubin measurements would have resulted in the same clinical decision as the reference standard. CONCLUSIONS: This evaluation supports use of BiliSpec to provide accurate, low-cost, point-of-care bilirubin measurements in low-resource hospitals. Future work is needed to evaluate BiliSpec among a larger number of users.Item Neonatal inpatient dataset for small and sick newborn care in low- and middle-income countries: systematic development and multi-country operationalisation with NEST360(Springer Nature, 2023) Cross, James H.; Bohne, Christine; Ngwala, Samuel K.; Shabani, Josephine; Wainaina, John; Dosunmu, Olabisi; Kassim, Irabi; Penzias, Rebecca E.; Tillya, Robert; Gathara, David; Zimba, Evelyn; Ezeaka, Veronica Chinyere; Odedere, Opeyemi; Chiume, Msandeni; Salim, Nahya; Kawaza, Kondwani; Lufesi, Norman; Irimu, Grace; Tongo, Olukemi O.; Malla, Lucas; Paton, Chris; Day, Louise T.; Oden, Maria; Richards-Kortum, Rebecca; Molyneux, Elizabeth M.; Ohuma, Eric O.; Lawn, Joy E.; Asibon, Aba; Adudans, Steve; Otiangala, Dickson; Mchoma, Christina; Yosefe, Simeon; Balogun, Adeleke; Omoke, Sylvia; Rashid, Ekran; Masanja, Honorati; English, Mike; Hagel, Christiane; with NEST360 Neonatal Inpatient Dataset Learning Group; Rice360 Institute for Global Health TechnologiesEvery Newborn Action Plan (ENAP) coverage target 4 necessitates national scale-up of Level-2 Small and Sick Newborn Care (SSNC) (with Continuous Positive Airway Pressure (CPAP)) in 80% of districts by 2025. Routine neonatal inpatient data is important for improving quality of care, targeting equity gaps, and enabling data-driven decision-making at individual, district, and national-levels. Existing neonatal inpatient datasets vary in purpose, size, definitions, and collection processes. We describe the co-design and operationalisation of a core inpatient dataset for use to track outcomes and improve quality of care for small and sick newborns in high-mortality settings.Item Target product profiles for neonatal care devices: systematic development and outcomes with NEST360 and UNICEF(Springer Nature, 2023) Kirby, Rebecca P.; Molyneux, Elizabeth M.; Dube, Queen; McWhorter, Cindy; Bradley, Beverly D.; Gartley, Martha; Oden, Z. Maria; Richards-Kortum, Rebecca; Werdenberg-Hall, Jennifer; Kumara, Danica; Liaghati-Mobarhan, Sara; Heenan, Megan; Bond, Meaghan; Ezeaka, Chinyere; Salim, Nahya; Irimu, Grace; Palamountain, Kara M.; Manasyan, Albert; Worm, Anna; Zuechner, Antke; Chepkemoi, Audrey; Tembo, Bentry; Trubo, Casey; Mudenyanga, Chishamiso; Wald, Daniel; Goldfarb, David; Gicheha, Edith; Asma, Elizabeth; Ciccone, Emily; Mbale, Emmie; Gheorghe, Florin; Dumont, Guy; Naburi, Helga; Pernica, Jeffrey; Appiah, John; Strysko, Jonathan; Langton, Josephine; Lawn, Joy; Klein, Kate; Kawaza, Kondwani; Gandrup-Marino, Kristoffer; Lloyd, Lizel; Woo Kinshella, Maggie; Chise, Mamiki; Myszkowski, Marc; Mkony, Martha Franklin; Waiyego, Mary; Khoory, Matthew; Medvedev, Melissa; Chiume, Msandeni; Spotswood, Naomi; Mataruse, Noah; Lufesi, Norman; Lincetto, Ornella; Lavoie, Pascal; Mbuthia, Rachel; Chifisi, Rhoda; Owino, Rita; Moshiro, Robert; Mbwasi, Ronald; Akech, Sam; Shah, Sona; Reschwamm, Steffen; Adudans, Steve; Mogotsi, Thabiso; Karlen, Walter; Demeke, Zelalem; the TPP Survey, Consensus Meeting Participants Collaborative Authorship Group; Rice360 Institute for Global Health TechnologiesMedical devices are critical to providing high-quality, hospital-based newborn care, yet many of these devices are unavailable in low- and middle-income countries (LMIC) and are not designed to be suitable for these settings. Target Product Profiles (TPPs) are often utilised at an early stage in the medical device development process to enable user-defined performance characteristics for a given setting. TPPs can also be applied to assess the profile and match of existing devices for a given context.