Browsing by Author "Calabrase, William"

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    Transforming Separation Science with Single-Molecule Methods
    (American Chemical Society, 2020) Calabrase, William; Bishop, Logan D.C.; Dutta, Chayan; Misiura, Anastasiia; Landes, Christy F.; Kisley, Lydia; Smalley-Curl Institute
    Empirical optimization of the multiscale parameters underlying chromatographic and membrane separations leads to enormous resource waste and production costs. A bottom-up approach to understand the physical phenomena underlying challenges in separations is possible with single-molecule observations of solute–stationary phase interactions. We outline single-molecule fluorescence techniques that can identify key interactions under ambient conditions. Next, we describe how studying increasingly complex samples heightens the relevance of single-molecule results to industrial applications. Finally, we illustrate how separation methods that have not been studied at the single-molecule scale can be advanced, using chiral chromatography as an example case. We hope new research directions based on a molecular approach to separations will emerge based on the ideas, technologies, and open scientific questions presented in this Perspective.