Browsing by Author "Adair, Antony"

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    Brain Radiation Necrosis Outside the Target Volume After Proton Radiation Therapy: Analyses of Multiparametric Imaging and Proton Biologic Effectiveness
    (Elsevier, 2022) Bronk, Julianna K.; Amer, Ahmad; Khose, Swapnil; Flint, David; Adair, Antony; Yepes, Pablo; Grosshans, David; Johnson, Jason; Chung, Caroline
    Purpose We present the case of a 48-year-old patient with recurrent World Health Organization grade II meningioma in the left occipital region who underwent a subtotal resection, followed by postoperative proton therapy to residual disease and the resection cavity. Fourteen months after radiation treatment completion, surveillance imaging revealed numerous ring-enhancing infratentorial lesions, both within and outside of the high-dose field, of concern for viable tumor. We describe the use of advanced imaging and proton biologic effectiveness analyses to enable the diagnosis of radiation necrosis (RN) and ascertain intrinsic physical factors contributing to the development of RN in this patient. Methods and Materials Multiparametric magnetic resonance imaging (MRI) and Monte Carlo predictions of linear energy transfer (LET) and variable relative biologic effectiveness dose were performed. Results The dosimetric analysis revealed that of the 10 lesions, 9 were located outside of the clinical treatment volume and 6 received a dose of <60 Gy relative biologic effectiveness to 95% of the volume. However, increased proton LET values were found in lesions that received lower radiation doses. Dynamic susceptibility contrast and contrast-enhanced, as well as arterial spin labeling-perfusion MRI findings were consistent with RN. Subsequent follow-up imaging revealed no further progression, and the patient was disease-free at the time of this report. Conclusions We describe a case of brain RN after proton beam radiation outside of the high-dose radiation therapy volume. On initial radiographic detection of these lesions, the distant relationship between their anatomic location with respect to the patient's treatment history reduced the suspicion of RN. However, on closer examination of intrinsic physical variables, RN lesions were present in regions that received a lower dose but higher LETs. Although conventional multisequence MRI was inadequate to distinguish between RN and tumor progression, characterization of tissue physiology allowed for the correct diagnosis, highlighting the utility of advanced brain tumor imaging in the follow-up setting.
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    Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy
    (Elsevier, 2019) Yepes, Pablo; Adair, Antony; Frank, Steven J.; Grosshans, David R.; Liao, Zhongxing; Liu, Amy; Mirkovic, Dragan; Poenisch, Falk; Titt, Uwe; Wang, Qianxia; Mohan, Radhe
    Purpose: To evaluate how using models of proton therapy that incorporate variable relative biological effectiveness (RBE) versus the current practice of using a fixed RBE of 1.1 affects dosimetric indices on treatment plans for large cohorts of patients treated with intensity modulated proton therapy (IMPT). Methods and Materials: Treatment plans for 4 groups of patients who received IMPT for brain, head-and-neck, thoracic, or prostate cancer were selected. Dose distributions were recalculated in 4 ways: 1 with a fast-dose Monte Carlo calculator with fixed RBE and 3 with RBE calculated to 3 different models—McNamara, Wedenberg, and repair-misrepair-fixation. Differences among dosimetric indices (D02, D50, D98, and mean dose) for target volumes and organs at risk (OARs) on each plan were compared between the fixed-RBE and variable-RBE calculations. Results: In analyses of all target volumes, for which the main concern is underprediction or RBE less than 1.1, none of the models predicted an RBE less than 1.05 for any of the cohorts. For OARs, the 2 models based on linear energy transfer, McNamara and Wedenberg, systematically predicted RBE >1.1 for most structures. For the mean dose of 25% of the plans for 2 OARs, they predict RBE equal to or larger than 1.4, 1.3, 1.3, and 1.2 for brain, head-and-neck, thorax, and prostate, respectively. Systematically lower increases in RBE are predicted by repair-misrepair-fixation, with a few cases (eg, femur) in which the RBE is less than 1.1 for all plans. Conclusions: The variable-RBE models predict increased doses to various OARs, suggesting that strategies to reduce high-dose linear energy transfer in critical structures should be developed to minimize possible toxicity associated with IMPT.