2021-03-022021-03-022020-10-20Nicolaou, Kyriacos C., Vourloumis, Dionisios, Yin, Jun, Erande, Rohan, Mandal, Debashis and Klahn, Phillipp, "Desacetoxytubulysin H and analogs thereof." Patent US10808007B2. issued 2020-10-20. Retrieved from <a href="https://hdl.handle.net/1911/110116">https://hdl.handle.net/1911/110116</a>.https://hdl.handle.net/1911/110116"In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. "259engUtility patentUS10808007B2