Haneef, ZulfiYang, KaiyuanSheth, Sameer A.Aloor, Fuad Z.Aazhang, BehnaamKrishnan, VaishnavKarakas, Cemal2022-08-092022-08-092022Haneef, Zulfi, Yang, Kaiyuan, Sheth, Sameer A., et al.. "Sub-scalp electroencephalography: A next-generation technique to study human neurophysiology." <i>Clinical Neurophysiology,</i> 141, (2022) Elsevier: 77-87. https://doi.org/10.1016/j.clinph.2022.07.003.https://hdl.handle.net/1911/113080Sub-scalp electroencephalography (ssEEG) is emerging as a promising technology in ultra-long-term electroencephalography (EEG) recordings. Given the diversity of devices available in this nascent field, uncertainty persists about its utility in epilepsy evaluation. This review critically dissects the many proposed utilities of ssEEG devices including (1) seizure quantification, (2) seizure characterization, (3) seizure lateralization, (4) seizure localization, (5) seizure alarms, (6) seizure forecasting, (7) biomarker discovery, (8) sleep medicine, and (9) responsive stimulation. The different ssEEG devices in development have individual design philosophies with unique strengths and limitations. There are devices offering primarily unilateral recordings (24/7 EEGTM SubQ, NeuroviewTM, Soenia® UltimateEEG™), bilateral recordings (Minder™, Epios™), and even those with responsive stimulation capability (EASEE®). We synthesize the current knowledge of these ssEEG systems. We review the (1) ssEEG devices, (2) use case scenarios, (3) challenges and (4) suggest a roadmap for ideal ssEEG designs.engThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/Journal article1-s2-0-S1388245722003273-mainhttps://doi.org/10.1016/j.clinph.2022.07.003