2019-02-222019-02-222018-08-14Judd, Justin, Suh, Junghae and Silberg, Jonathan, "Encryption of adeno-associated viruses with enzymatically decoded peptide locks." Patent US10047128B2. issued 2018-08-14. Retrieved from <a href="https://hdl.handle.net/1911/105159">https://hdl.handle.net/1911/105159</a>.https://hdl.handle.net/1911/105159The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface.27engUtility patentUS10047128B2