Nagrath, Deepak2016-01-262016-01-262015-122015-11-24December 2Salimian Rizi, Bahar. "Nitric Oxide: The Missing Link in Omentum-Induced Metabolic reprogramming of ovarian cancers." (2015) Diss., Rice University. <a href="https://hdl.handle.net/1911/88140">https://hdl.handle.net/1911/88140</a>.https://hdl.handle.net/1911/88140A novel metabolic regulatory mechanism of ovarian cancer by omentum adipose-derived stroma cells (O-ASCs) has been discovered. O-ASCs induce survival, migration, and chemoresistance of ovarian cancer cells. However, the underpinning mechanism behind the metabolic modulation was not understood. Here, O-ASCs are shown to promote nitric oxide (NO) homeostasis in ovarian cancers by generating the pool of arginine. Ovarian cancer cells benefit from tumor microenvironment’s elements and expand their growth. In turn, cancer cells modify the elements’ fate to further take advantage of nutrients and resources. A unique combinatory drug treatment is proposed to target O-ASCs-induced chemoresistance of ovarian cancer cells.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Ovarian cancer metabolismtumor microenvironmentcancer metabolismnitric oxidearginine metabolismomentumThesis2016-01-26