Janus, PatrykKuś, PawełJaksik, RomanVydra, NataliaToma-Jonik, AgnieszkaGramatyka, MichalinaKurpas, MonikaKimmel, MarekWidłak, Wiesława2024-11-202024-11-202024Janus, P., Kuś, P., Jaksik, R., Vydra, N., Toma-Jonik, A., Gramatyka, M., Kurpas, M., Kimmel, M., & Widłak, W. (2024). Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells. Cell Communication and Signaling, 22(1), 522. https://doi.org/10.1186/s12964-024-01821-5https://hdl.handle.net/1911/118062Transforming growth factor beta (TGFβ) is important for the morphogenesis and secretory function of the mammary gland. It is one of the main activators of the epithelial–mesenchymal transition (EMT), a process important for tissue remodeling and regeneration. It also provides cells with the plasticity to form metastases during tumor progression. Noncancerous and cancer cells respond differently to TGFβ. However, knowledge of the cellular signaling cascades triggered by TGFβ in various cell types is still limited.engExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Journal articleBystander effectCell deathEMTCell cycleEstrogen signalingMammary epithelial cellsMCF10AMCF7TGFβ signalings12964-024-01821-5https://doi.org/10.1186/s12964-024-01821-5