Camley, Brian A.Zhao, YanxiangLi, BoLevine, HerbertRappel, Wouter-Jan2016-02-052016-02-052013Camley, Brian A., Zhao, Yanxiang, Li, Bo, et al.. "Periodic Migration in a Physical Model of Cells on Micropatterns." <i>Physical Review Letters,</i> 111, no. 15 (2013) American Physical Society: 158102. http://dx.doi.org/10.1103/PhysRevLett.111.158102.https://hdl.handle.net/1911/88400We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by actin and myosin. We propose that protrusive stresses are only generated where the cell adheres, leading to the cellﾒs effective confinement to the pattern. Consistent with experimental results, simulated cells exhibit a broad range of behaviors, including steady motion, turning, bipedal motion, and periodic migration, in which the cell crawls persistently in one direction before reversing periodically. We show that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlehttp://dx.doi.org/10.1103/PhysRevLett.111.158102