Alexander, Leila T.Durairaj, JananiKryshtafovych, AndriyAbriata, Luciano A.Bayo, YusuphaBhabha, GiraBreyton, CécileCaulton, Simon G.Chen, JamesDegroux, SéraphineEkiert, Damian C.Erlandsen, Benedikte S.Freddolino, Peter L.Gilzer, DominicGreening, ChrisGrimes, Jonathan M.Grinter, RhysGurusaran, ManickamHartmann, Marcus D.Hitchman, Charlie J.Keown, Jeremy R.Kropp, AshleighKursula, PetriLovering, Andrew L.Lemaitre, BrunoLia, AndreaLiu, ShihengLogotheti, MariaLu, ShuzeMarkússon, SigurbjörnMiller, Mitchell D.Minasov, GeorgeNiemann, Hartmut H.Opazo, FelipePhillips Jr, George N.Davies, Owen R.Rommelaere, SamuelRosas-Lemus, MonicaRoversi, PietroSatchell, KarlaSmith, NathanWilson, Mark A.Wu, Kuan-LinXia, XianXiao, HanZhang, WenhuaZhou, Z. HongFidelis, KrzysztofTopf, MayaMoult, JohnSchwede, Torsten2024-05-032024-05-032023Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., Ekiert, D. C., Erlandsen, B. S., Freddolino, P. L., Gilzer, D., Greening, C., Grimes, J. M., Grinter, R., Gurusaran, M., Hartmann, M. D., … Schwede, T. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91(12), 1571–1599. https://doi.org/10.1002/prot.26545https://hdl.handle.net/1911/115537We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.engExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Journal articleProtein-target-highlightshttps://doi.org/10.1002/prot.26545