Poulose, Aby CheruvathoorVeeranarayanan, SrivaniMohamed, M. SheikhNagaoka, YutakaAburto, Rebeca RomeroMitcham, TrevorAjayan, Pulickel M.Bouchard, Richard R.Sakamoto, YasushiYoshida, YasuhikoMaekawa, ToruKumar, D. Sakthi2016-08-302016-08-302015Poulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M. Sheikh, et al.. "Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents." <i>Nanoscale,</i> 7, (2015) Royal Society of Chemistry: 8378-8388. http://dx.doi.org/10.1039/C4NR07139E.https://hdl.handle.net/1911/91373A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.Journal articlehttp://dx.doi.org/10.1039/C4NR07139E