Bondos, Sarah E.Swint-Kruse, LiskinMatthews, Kathleen S.2015-10-122015-10-122015Bondos, Sarah E., Swint-Kruse, Liskin and Matthews, Kathleen S.. "Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins." <i>The Journal of Biological Chemistry,</i> 290, (2015) American Society for Biochemistry and Molecular Biology: 24669-24677. http://dx.doi.org/10.1074/jbc.R115.685032.https://hdl.handle.net/1911/81874To modulate transcription, a variety of input signals must be sensed by genetic regulatory proteins. In these proteins, flexibility and disorder are emerging as common themes. Prokaryotic regulators generally have short, flexible segments, whereas eukaryotic regulators have extended regions that lack predicted secondary structure (intrinsic disorder). Two examples illustrate the impact of flexibility and disorder on gene regulation: the prokaryotic LacI/GalR family, with detailed information from studies on LacI, and the eukaryotic family of Hox proteins, with specific insights from investigations of Ultrabithorax (Ubx). The widespread importance of structural disorder in gene regulatory proteins may derive from the need for flexibility in signal response and, particularly in eukaryotes, in protein partner selection.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Society for Biochemistry and Molecular Biology.Journal articleDNADNA operatorDNA-binding proteinHox proteinsLacI/GalR proteinsUltrabithoraxgene regulationintrinsic disorderprotein flexibilityrepressor proteintranscription factorhttp://dx.doi.org/10.1074/jbc.R115.685032