Ciufolini, Marco A.2009-06-042009-06-041992Shimizu, Toshio. "Synthetic studies towards the luzopeptins: New amino acid synthons through the aza-Achmatowicz reaction." (1992) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13607">https://hdl.handle.net/1911/13607</a>.https://hdl.handle.net/1911/13607A new method for the enantioselective synthesis of unusual amino acids has been developed. The chemoenzymatic aza-Achmatowicz rearrangement of appropriate furylglycine derivatives provided nitrogenous synthons that were readily converted to amino acid building blocks. An application of the new chemistry to the synthesis of the unique pyridazine carboxylic acid component of luzopeptins is presented. Luzopeptin C has potent inhibitory activity towards the reverse transcriptase of HIV as the causative agent of AIDS.122 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Organic chemistryPharmaceutical chemistryThesisThesis Chem. 1992 Shimizu