Carbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentation

2015-05-042015-05-042008-08-19Sivarajan, Ramesh, Hauge, Robert H. and Marriott, Terry, "Carbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentation." Patent US7413907B2. issued 2008-08-19. Retrieved from https://hdl.handle.net/1911/79975.https://hdl.handle.net/1911/79975The present invention is directed toward novel matrix elements, generally comprising functionalized carbon nanotubes, for matrix-assisted laser desorption ionization (MALDI)-mass spectroscopy (MS), methods of making such matrix elements, and to methods of using such matrix elements in MALDI-MS applications, particularly for the analysis of biological molecules. In some embodiments, by carefully tuning the absorption characteristics of the matrix element, biomolecular analytes can be sequenced.13 ppengCarbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentationUtility patentUS7413907B2