Foley, Joseph D. IIISneed, J. DarrellSteinhubl, Steven R.Kolasa, Justin R.Ebersole, Jeffrey L.Lin, YushunKryscio, Richard J.McDevitt, John T.Campbell, Charles L.Miller, Craig S.2017-08-022017-08-022012Foley, Joseph D. III, Sneed, J. Darrell, Steinhubl, Steven R., et al.. "Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model." <i>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,</i> 114, no. 5 (2012) Elsevier: 616-623. https://doi.org/10.1016/j.oooo.2012.05.024.https://hdl.handle.net/1911/96165Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P < .01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P < .02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P < .001). Conclusions: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.Journal articleSalivary_Biomarkershttps://doi.org/10.1016/j.oooo.2012.05.024