2021-03-022021-03-022021-01-12Nicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S. and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US10889590B2. issued 2021-01-12. Retrieved from <a href="https://hdl.handle.net/1911/110128">https://hdl.handle.net/1911/110128</a>.https://hdl.handle.net/1911/110128In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.103engUtility patentUS10889590B2