Nicolaou, K.C.Heretsch, PhilippElMarrouni, AbdelatifHale, Christopher R.H.Pulukuri, Kiran K.Kudva, Avinash K.Narayan, VivekPrabhu, K. Sandeep2015-10-292015-10-292014Nicolaou, K.C., Heretsch, Philipp, ElMarrouni, Abdelatif, et al.. "Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent." <i>Angewandte Chemie,</i> 126, no. 39 (2014) Wiley: 10611-10615. http://dx.doi.org/10.1002/ange.201404917.https://hdl.handle.net/1911/81982A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.Journal articleasymmetric catalysisC-H activationleukemianatural productstotal synthesishttp://dx.doi.org/10.1002/ange.201404917