Choi, Mi-RanBardhan, RiziaStanton-Maxey, Katie J.Badve, SunilNakshatri, HarikrishnaStantz, Keith M.Cao, NingHalas, Naomi J.Clare, Susan E.2013-03-142013-03-142012Choi, Mi-Ran, Bardhan, Rizia, Stanton-Maxey, Katie J., et al.. "Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse." <i>Cancer Nanotechnology,</i> 3, (2012) Springer: 47-54. http://dx.doi.org/10.1007/s12645-012-0029-9.https://hdl.handle.net/1911/70591As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlebreast cancerbrain metastasisgold-silica nanoshellnanoparticleblood-brain barrierhttp://dx.doi.org/10.1007/s12645-012-0029-9