Xie, Chong2024-01-222024-01-222023-122023-11-28December 2Yip, Victor. "Minimally invasive reliable implantation of ultra-flexible electrodes for non-human primates." (2023) Master's thesis, Rice University. https://hdl.handle.net/1911/115358https://hdl.handle.net/1911/115358EMBARGO NOTE: This item is embargoed until 2025-12-01Ultra-flexible nanoelectric threads (NETs) have been successful in recording neural data in high densities in the cortical and sub-cortical regions, while avoiding post-surgery complications such as foreign-body responses or additional glial scarring from motion when compared to rigid electrodes. Studying sub-cortical brain function is important to understand lower-level brain activity and is mostly exclusive to microelectrodes that can be positioned close to the neurons of interest. To deliver the NET into the brain, a stiff shuttle is used to penetrate the brain tissue. The current T-shaped needle-and-thread shuttle has been successful for transdural implantation in rodents but struggles to scale to larger models. In this thesis, we intend to demonstrate the following: (1) The hook shuttle can be fabricated and successfully and reliably delivers NETs into the brain in rodent models. (2) The hook shuttle performs better than the T-shape shuttle by decreasing the required insertion force. (3) A cannula can be fabricated to help a shuttle deliver NETs into a non-human primate brain by reducing the required insertion force, demonstrated with parafilm and agarose gel phantoms.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.non-human primatesultra-flexible electrodesmouseimplantationbrainThesis2024-01-22