Hernandez, AndreaHartgerink, Jeffrey D.Young, Simon2023-04-252023-04-252023Hernandez, Andrea, Hartgerink, Jeffrey D. and Young, Simon. "Self-assembling peptides as immunomodulatory biomaterials." <i>Frontiers in Bioengineering and Biotechnology,</i> 11, (2023) Frontiers Media S.A.: https://doi.org/10.3389/fbioe.2023.1139782.https://hdl.handle.net/1911/114836Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides’ characteristics and current applications in immunomodulatory therapeutics.engThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Journal articlefbioe-11-1139782https://doi.org/10.3389/fbioe.2023.1139782