Rafferty, Megan S.Burrows, HannahJoseph, Jake P.Leveille, JenniferNihtianova, SnejanaAmirian, E. Susan2021-03-232021-03-232021Rafferty, Megan S., Burrows, Hannah, Joseph, Jake P., et al.. "Multisystem inflammatory syndrome in children (MIS-C) and the coronavirus pandemic: Current knowledge and implications for public health." <i>Journal of Infection and Public Health,</i> 14, no. 4 (2021) Elsevier: 484-494. https://doi.org/10.1016/j.jiph.2021.01.008.https://hdl.handle.net/1911/110186The coronavirus disease 2019 (COVID-19) pandemic has caused widespread mortality and morbidity. Though children are largely spared from severe illness, a novel childhood hyperinflammatory syndrome presumed to be associated with and subsequent to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged with potentially severe outcomes. Multisystem inflammatory disorder in children (MIS-C) most commonly affects young, school-aged children and is characterized by persistent fever, systemic hyperinflammation, and multisystem organ dysfunction. While uncommon and generally treatable, MIS-C presents potentially life-altering medical sequelae, complicated by a dearth of information regarding its etiology, pathophysiology, and long-term outcomes. The severity of MIS-C may warrant the need for increased awareness and continued COVID-19 mitigation efforts, particularly until potential factors conferring a predisposition to MIS-C can be clarified through additional research. Well-informed guidelines will be critical as the school year progresses. In this article, current knowledge on MIS-C is reviewed and the potential implications of this novel syndrome are discussed from a public health perspective.engThis is an open access article under the CC BY-NC-ND licenseJournal articleMultisystem inflammatory disorder in children;Pediatric inflammatory multisystem syndrome;Coronavirus;MIS-C;PIMS;COVID-19https://doi.org/10.1016/j.jiph.2021.01.008