Fukuyama, Tohru2009-06-042009-06-041988Nunes, Joseph John. "A total synthesis of (+,-)-quinocarcin." (1988) Diss., Rice University. <a href="https://hdl.handle.net/1911/16174">https://hdl.handle.net/1911/16174</a>.https://hdl.handle.net/1911/16174A synthetic route via the key intermediate DX-52-1 21 has resulted in the first total synthesis of the complex antitumor antibiotic quinocarcin 1. Salient features include an acyliminium ion-mediated stereoselective construction of a diazabicyclo (3.2.1) octane nucleus, a stereoselective Pictet-Spengler cyclization, and a silver assisted conversion of DX-52-1 to the title compound.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)172 p.application/pdfengCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Organic chemistryThesisThesis Chem. 1988 Nunes