Tian, ZeruWu, LingYu, ChenfeiChen, YudaXu, ZhanBado, IgorLoredo, AxelWang, LushunWang, HaiWu, Kuan-LinZhang, WeijieZhang, Xiang H.-F.Xiao, Han2021-07-082021-07-082021Tian, Zeru, Wu, Ling, Yu, Chenfei, et al.. "Harnessing the power of antibodies to fight bone metastasis." <i>Science Advances,</i> 7, no. 26 (2021) AAAS: https://doi.org/10.1126/sciadv.abf2051.https://hdl.handle.net/1911/111000Antibody-based therapies have proved to be of great value in cancer treatment. Despite the clinical success of these biopharmaceuticals, reaching targets in the bone microenvironment has proved to be difficult due to the relatively low vascularization of bone tissue and the presence of physical barriers. Here, we have used an innovative bone-targeting (BonTarg) technology to generate a first-in-class bone-targeting antibody. Our strategy involves the use of pClick antibody conjugation technology to chemically couple the bone-targeting moiety bisphosphonate to therapeutic antibodies. Bisphosphonate modification of these antibodies results in the delivery of higher conjugate concentrations to the bone metastatic niche, relative to other tissues. In xenograft mice models, this strategy provides enhanced inhibition of bone metastases and multiorgan secondary metastases that arise from bone lesions. Specific delivery of therapeutic antibodies to the bone, therefore, represents a promising strategy for the treatment of bone metastatic cancers and other bone diseases. Precision modification of antibodies with bone-targeting moieties unleashes their potential for the treatment of bone metastases. Precision modification of antibodies with bone-targeting moieties unleashes their potential for the treatment of bone metastases.engThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.Journal articleeabf2051-fullhttps://doi.org/10.1126/sciadv.abf2051