He, HongxingFang, HengruiMiller, Mitchell D.Phillips, George N.Jr.Su, Wu-Pei2016-11-102016-11-102016He, Hongxing, Fang, Hengrui, Miller, Mitchell D., et al.. "Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm." <i>Acta Crystallographica,</i> A72, (2016) International Union of Crystallography: 539-547. http://dx.doi.org/10.1107/S2053273316010731.https://hdl.handle.net/1911/92704An iterative transform method proposed previously for direct phasing of high-solvent-content protein crystals is employed for enhancing the molecular-replacement (MR) algorithm in protein crystallography. Target structures that are resistant to conventional MR due to insufficient similarity between the template and target structures might be tractable with this modified phasing method. Trial calculations involving three different structures are described to test and illustrate the methodology. The relationship of the approach toﾠPHENIX Phaser-MRﾠandﾠMR-Rosettaﾠis discussed.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlemolecular replacementhybrid inputﾖoutput algorithmab initio phasingprotein crystallographyhttp://dx.doi.org/10.1107/S2053273316010731