Wickremasinghe, Navindee C.Kumar, Vivek A.Shi, SiyuHartgerink, Jeffrey D.2017-05-122017-05-122015Wickremasinghe, Navindee C., Kumar, Vivek A., Shi, Siyu, et al.. "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels." <i>ACS Biomaterials Science & Engineering,</i> 1, no. 9 (2015) American Chemical Society: 845-854. http://dx.doi.org/10.1021/acsbiomaterials.5b00210.https://hdl.handle.net/1911/94235Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices. Scaffolds showed expected rapid infiltration of macrophages. When released through liposomes incorporated in MDP gels (MDP(Lipo)), PlGF-1 modulates HUVEC VEGF receptor activation in vitro and robust vessel formation in vivo. These loaded MDP(Lipo) hydrogels induce a high level of growth-factor-mediated neovascular maturity. MDP(Lipo) hydrogels offer a biocompatible and injectable platform to tailor drug delivery and treat ischemic tissue diseases.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.Journal articleself-assemblymultidomain peptideliposomal encapsulationPlGF-1cellular infiltrationangiogenesishttp://dx.doi.org/10.1021/acsbiomaterials.5b00210