He, FeiLycke, RoyGanji, MehranXie, ChongLuan, Lan2020-11-032020-11-032020He, Fei, Lycke, Roy, Ganji, Mehran, et al.. "Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording." <i>iScience,</i> 23, no. 8 (2020) Cell Press: https://doi.org/10.1016/j.isci.2020.101387.https://hdl.handle.net/1911/109491Implanted electrodes provide one of the most important neurotechniques for fundamental and translational neurosciences by permitting time-resolved electrical detection of individual neurons in vivo. However, conventional rigid electrodes typically cannot provide stable, long-lasting recordings. Numerous interwoven biotic and abiotic factors at the tissue-electrode interface lead to short- and long-term instability of the recording performance. Making neural electrodes flexible provides a promising approach to mitigate these challenges on the implants and at the tissue-electrode interface. Here we review the recent progress of ultraflexible neural electrodes and discuss the engineering principles, the material properties, and the implantation strategies to achieve stable tissue-electrode interface and reliable unit recordings in living brains.engThis is an open access article under the CC BY-NC-ND licenseJournal articlehttps://doi.org/10.1016/j.isci.2020.101387