2017-12-142017-12-142017-10-03Nicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US9777013B2. issued 2017-10-03. Retrieved from <a href="https://hdl.handle.net/1911/98878">https://hdl.handle.net/1911/98878</a>.https://hdl.handle.net/1911/98878In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).106engUtility patentUS9777013B2