Zhang, ShunyaoMiao, JingyiLi, Lei S.2024-08-072024-08-072024Zhang, S., Miao, J., & Li, L. S. (2024). Challenges and advances in two-dimensional photoacoustic computed tomography: A review. Journal of Biomedical Optics, 29(7), 070901. https://doi.org/10.1117/1.JBO.29.7.070901https://hdl.handle.net/1911/117590SignificancePhotoacoustic computed tomography (PACT), a hybrid imaging modality combining optical excitation with acoustic detection, has rapidly emerged as a prominent biomedical imaging technique.AimWe review the challenges and advances of PACT, including (1) limited view, (2) anisotropy resolution, (3) spatial aliasing, (4) acoustic heterogeneity (speed of sound mismatch), and (5) fluence correction of spectral unmixing.ApproachWe performed a comprehensive literature review to summarize the key challenges in PACT toward practical applications and discuss various solutions.ResultsThere is a wide range of contributions from both industry and academic spaces. Various approaches, including emerging deep learning methods, are proposed to improve the performance of PACT further.ConclusionsWe outline contemporary technologies aimed at tackling the challenges in PACT applications.engExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Journal article070901_1https://doi.org/10.1103/10.1117/1.JBO.29.7.070901