Matson, Michael L.Villa, Carlos H.Ananta, Jeyarama S.Law, Justin J.Scheinberg, David A.Wilson, Lon J.2016-06-222016-06-222015Matson, Michael L., Villa, Carlos H., Ananta, Jeyarama S., et al.. "Encapsulation of α-Particle–Emitting225Ac3+ Ions Within Carbon Nanotubes." <i>The Journal of Nuclear Medicine,</i> 56, no. 6 (2015) Society of Nuclear Medicine and Molecular Imaging: 897-900. http://dx.doi.org/10.2967/jnumed.115.158311.https://hdl.handle.net/1911/90523225Ac3+ is a generator of α-particle–emitting radionuclides with 4 net α-particle decays that can be used therapeutically. Targeting 225Ac3+ by use of ligands conjugated to traditional bifunctional chelates limits the amount of 225Ac3+ that can be delivered. Ultrashort, single-walled carbon nanotubes (US-tubes), previously demonstrated as sequestering agents of trivalent lanthanide ions and small molecules, also successfully incorporate 225Ac3+. Methods: Aqueous loading of both 225Ac3+ ions and Gd3+ ions via bath sonication was used to construct 225Ac@gadonanotubes (225Ac@GNTs). The 225Ac@GNTs were subsequently challenged with heat, time, and human serum. Results: US-tubes internally loaded with both 225Ac3+ ions and Gd3+ ions show 2 distinct populations of 225Ac3+ ions: one rapidly lost in human serum and one that remains bound to the US-tubes despite additional challenge with heat, time, and serum. The presence of the latter population depended on cosequestration of Gd3+ and 225Ac3+ ions. Conclusion: US-tubes successfully sequester 225Ac3+ ions in the presence of Gd3+ ions and retain them after a human serum challenge, rendering 225Ac@GNTs candidates for radioimmunotherapy for delivery of 225Ac3+ ions at higher concentrations than is currently possible for traditional ligand carriers.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Society of Nuclear Medicine and Molecular Imaging.Journal article225Accarbon nanotubealpha therapynanotechnologyhttp://dx.doi.org/10.2967/jnumed.115.158311