Osei, Manasseh KusiMirzaei, SaberMirzaei, M. SaeedValles, AgustinSánchez, Raúl Hernández2024-07-252024-07-252024Kusi Osei, M., Mirzaei, S., Saeed Mirzaei, M., Valles, A., & Sánchez, R. H. (2024). Reversible dioxygen uptake at [Cu 4 ] clusters. Chemical Science, 15(14), 5327–5332. https://doi.org/10.1039/D3SC06390Ahttps://hdl.handle.net/1911/117509Dioxygen binding solely through non-covalent interactions is rare. In living systems, dioxygen transport takes place via iron or copper-containing biological cofactors. Specifically, a reversible covalent interaction is established when O2 binds to the mono or polynuclear metal center. However, O2 stabilization in the absence of covalent bond formation is challenging and rarely observed. Here, we demonstrate a unique example of reversible non-covalent binding of dioxygen within the cavity of a well-defined synthetic all-Cu(I) tetracopper cluster.engExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.Journal articled3sc06390ahttps://doi.org/10.1039/D3SC06390A