Gupta, ChinmayaLópez, José ManuelOtt, WilliamJosić, KrešimirBennett, Matthew R.2014-01-212014-01-212013-08Gupta, Chinmaya, López, José Manuel, Ott, William, et al.. "Transcriptional Delay Stabilizes Bistable Gene Networks." <i>Physical Review Letters,</i> 111, no. 5 (2013) American Physical Society: 58104. http://dx.doi.org/10.1103/PhysRevLett.111.058104.https://hdl.handle.net/1911/75346Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.engArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.Journal articlehttp://dx.doi.org/10.1103/PhysRevLett.111.058104