Minus, Matthew B.Liu, WeiVohidov, FarrukhKasembeli, Moses M.Long, XinKrueger, MichaelStevens, AlexandraKolosov, Mikhail I.Tweardy, David J.Sison, Edward Allen R.Redell, Michele S.Ball, Zachary T.2017-05-122017-05-122015Minus, Matthew B., Liu, Wei, Vohidov, Farrukh, et al.. "Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity." <i>Angewandte Chemie International Edition,</i> 54, no. 44 (2015) Wiley: 13085-13089. http://dx.doi.org/10.1002/anie.201506889.https://hdl.handle.net/1911/94238Nearly 40 % of children with acute myeloid leukemia (AML) suffer relapse arising from chemoresistance, often involving upregulation of the oncoprotein STAT3 (signal transducer and activator of transcription 3). Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML.engThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.Journal articlehttp://dx.doi.org/10.1002/anie.201506889